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Caffeine +

Advanced caffeine-based nootropic formula for cleaner, smarter energy. Delivering a calm, controlled caffeine kick without the downsides.*

  • Smooth energy. Clarity. Focus. No jitters. No burnout. No crash.*
  • 7 research-backed ingredients in 1 clean, convenient capsule.*
  • Natural Caffeine + L-Theanine, L-Tyrosine and NutriGenesis® B-vitamins.*
Upgrade Yourself®with Performance Lab® Caffeine Plus

Experience balanced, optimized and productive caffeine stimulation

Basic stimulant supplements’ caffeine megadoses lead to short-term jitters and long-range exhaustion. They also often include synthetic colors, preservatives and flavors.

Performance Lab® Caffeine Plus is smarter and cleaner. With Natural Caffeine 50 mg + Suntheanine® 100 mg, it delivers greater dosing precision, fewer side effects and superior performance-tuned stimulation.

Caffeine Plus’s ultramodern design also helps restore caffeine-depleted brain chemicals with L-Tyrosine + NutriGenesis® B-Complex – supporting healthy recovery from all caffeine-driven activities.

Caffeine Plus

How to take

Caffeine Plus supplies 50 mg of clean, precisely dosed caffeine stimulation per capsule. Take more as required – up to a maximum of 5 capsules (250 mg) per day. For a calm, controlled caffeine ‘kick’ without the negative side effects.

Ultramodern Design

Caffeine Plus is the future of caffeine stimulation. Caffeine 2.0. Intelligently designed to counterbalance the natural caffeine with an ultramodern cocktail of advanced-form nutrients. Restoring caffeine-depleted brain chemicals to support clean, relaxed energy with faster, healthier recovery.

Easy to swallow

Easy to swallow

Caffeine Plus is delivered in convenient, easy-to-swallow 0-sized NutriCaps®. 100% plant-based capsules made from pullulan (fermented tapioca) that are ultraclean and naturally prebiotic-infused. Supporting comfortable digestion and superior nutrient absorption into your body.

Designed for Performance

  • Caffeine enhanced for superior nootropic, athletic and thermogenic performance*
  • Raises Alpha brainwaves to balance caffeine energy with relaxation, creativity and clarity*
  • Promotes alert, revitalized performance during multitasking, stress and fatigue*
  • Helps reduce jitters, crashes and other negative effects of caffeine overstimulation*

Healthy for Daily Use

  • Helps replenish caffeine-depleted brain chemicals, for daily use with less burnout*
  • 50 mg caffeine serving size for dosing precision, stacking safety and stim control
  • Promotes balanced physiological responses to caffeine-induced stress*
  • Patented, cutting-edge nutrients from Suntheanine® and NutriGenesis®

Ingredients

Supplement Facts

Serving Size: 1 NutriCap®

Servings per container: 30

Amount Per
NutriCap®
% Daily
Value
NutriGenesis® Caffeine Balance B-Complex
Riboflavin (Vitamin B2) 500 mcg 38%
Vitamin B6 (from NutriGenesis®) 750 mcg 44%
Folate (Vitamin B9) 170 mcg DFE 42.5%
Vitamin B12 (from NutriGenesis®) 2 mcg 83%
Natural Caffeine (from Coffea robusta seeds) 50 mg
L-Theanine 100 mg
L-Tyrosine 250 mg
Daily Values are based on a 2,000 calories per day diet.
† Daily Value not established.

Other Ingredients: NutriCaps® Pullulan Capsule, NuFlow® Rice Concentrate.

Suitable for vegans. Contains NO soy, egg, fish, shellfish, dairy, peanut, tree nuts, wheat, or other allergens. Non-GMO and non-irradiated. Free of gluten, synthetic additives, artificial colors and preservatives.

Suggested Use: Take 1 capsule for stimulation. Take up to 5 capsules daily. For advanced usage guidelines visit www.performancelab.com/Advanced

NutriGenesis® and NutriCaps® are registered trademarks of XGen Biotech Ltd.

BPA Free. Please Recycle.

The Science

Experience Ultramodern Performance-Enhanced Caffeine

Caffeine helps with several key aspects of performance:

  • Nootropic
    Caffeine improves alertness, mood, memory, focus and mental energy
  • Athletic
    Caffeine amplifies intensity, endurance, physical energy and competitive performance
  • Thermogenic
    Caffeine raises metabolic performance to help with fat burning and weight management

Concern: Caffeine can knock the body off balance – potentially leading to stress, overstimulation, fight-or-flight jitters and other performance-limiting side effects.

Performance Lab® Caffeine Plus improves caffeine’s performance-enhancing effects with an innovative dual-stack formula designed for cleaner, calmer stimulation.

Stack 1: Performance-Tuned Stimulation

L-Theanine + Caffeine is popularly used to reduce caffeine side effects. Human clinical trials also show L-Theanine + Caffeine may produce a superior stimulation state to caffeine alone, as evidenced by:

  1. Enhanced attention-switching performance and strengthened resistance to distractions;
  2. Improved vigilance; sustained focus on monotonous tasks over a longer time;
  3. Increased alertness, reduced tiredness and improved accuracy during multitasking.

L-Theanine’s additional mood, creativity and relaxation benefits also pair well with caffeine stimulation.

Performance Lab® Caffeine Plus is designed with 2:1 Suntheanine® L-Theanine to natural caffeine, mirroring the ratio and form used in the most successful human research studies.

Stack 2: Caffeine Balance and Recovery

Caffeine stimulation increases demands on the body’s central nervous system (CNS), endocrine system and cardiovascular system. When these systems are stressed, caffeine side effects may manifest.

Performance Lab® Caffeine Plus counterbalances caffeine demands with Suntheanine® L-Theanine, L-Tyrosine and NutriGenesis® B-Vitamins.

Caffeine Demands Performance Lab® Caffeine Plus Counterbalance
Increases demand on neurotransmitters:
  • Dopamine
  • Serotonin
  • Epinephrine
  • Norepinephrine

L-Tyrosine – Supports dopamine, norepinephrine, epinephrine

L-Theanine – Promotes dopamine and serotonin

B-Complex – Supports serotonin and norepinephrine; catalyzes conversion and utilization of serotonin and dopamine

Decreases Alpha brain waves L-Theanine – Raises and sustains Alpha brain waves
Creates fight-or-flight stress that activates hypothalamic pituitary adrenal (HPA) axis; stimulates adrenal glands to release stress hormone cortisol

L-Theanine – Regulates cortisol and promotes relaxation

L-Tyrosine – Optimizes mental and physical performance under stress

B-Complex – Helps meet increased demands of stressed adrenals

Constricts blood vessels, raising blood pressure; accelerates heart rate L-Theanine – Helps to maintain healthy blood pressure within normal range; helps to reduce resting heart rate
Diuretic effects increase excretion of B-Vitamins needed for cell energy and brain chemical synthesis B-Complex – Highly absorbable NutriGenesis® B-Vitamins to help restore what caffeine takes away
Raises homocysteine (HCY) levels; high HCY linked to brain fog and memory issues B-Complex – Contributes to daily B6, B9 and B12 intake required for healthy homocysteine metabolism

Performance Lab® Caffeine Plus’s innovative caffeine stack produces a superior stimulation state:

  • Stronger resistance to caffeine-induced physical and mental stress;
  • Fewer jitters, anxiety concerns, heart rate issues, and other side effects;
  • Healthier recovery and a faster bounceback from stimulation;
  • Enhanced performance whether you are working, training, creating or just seeking clean vitality.

Natural Caffeine, 50 mg

When taken correctly, caffeine is a leading natural performance enhancer. However, too much caffeine can lead to overstimulation that paradoxically worsens performance:

Caffeine and Performance

To get the best performance benefits, individuals must determine their own optimal caffeine dose and manage caffeine intake accordingly.

This can be challenging for those who consume caffeine from many different sources.

Caffeine Plus’s 50 mg dose improves caffeine intake control – whether taken alone or combined with coffee, energy drinks or other Performance Lab® formulas.

Suntheanine® L-Theanine, 100 mg

Suntheanine® L-Theanine

L-Theanine supports calm, clear thinking and can reduce caffeine side effects.

L-Theanine is an amino acid found in green tea that raises the brain’s Alpha wave frequency (8-14 Hz). Amplified Alpha brain waves are associated with several cognitive benefits, including:

  • Wakeful relaxation: A state of calm clarity without sedation
  • Enhanced creativity and free-form cognitive exploration
  • Reduced anxiety and improved mood balance

In addition to raising Alpha brain waves, L-Theanine has been suggested to:

  1. Support dopamine, GABA and serotonin brain chemicals for a calm, motivated state of mind;
  2. Blunt excitatory brain chemicals to tone down an overstimulated central nervous system (CNS);
  3. Support blood pressure and heart rate in normal range, reflecting its overall CNS-relaxing effects.

Caffeine Plus L-Theanine enhances caffeine to promote calmer, cleaner stimulation that is precision-tuned for peak human performance.

Performance Lab® Caffeine Plus Suntheanine® is 100% pure, nature-identical L-isomer-Theanine clinically shown to raise Alpha brainwaves. Suntheanine® is protected by 40+ nutritional technology patents. Stim’s 100 mg Suntheanine® supplies L-Theanine equivalent to what is found in 10 cups of green tea.

L-Tyrosine, 250 mg

Caffeine works by blocking adenosine, a depressant hormone that signals for fatigue and drowsiness. This initiates a cascade of stimulatory catecholamine neurotransmitters that produce caffeine’s familiar psychostimulant effects:

  • Dopamine – Pleasure, attention, motivation, reward
  • Norepinephrine – Vigilance, focus, alertness, awareness
  • Epinephrine (adrenaline) – Energy rush, heart rate, muscle strength

Concern: Caffeine stimulation increases demand on catecholamines. Low catecholamine levels are linked with attention problems, mood imbalance, short-term crashing and long-range exhaustion.

L-Tyrosine helps by supporting the synthesis and recycling of catecholamine neurotransmitters that are most impacted by caffeine.

L-Tyrosine also enhances caffeine stimulation with research-backed cognitive benefits for:

  • Working memory
  • Thinking under fatigue
  • Multitasking performance
  • Stress resistance
L-Tyrosine

L-Tyrosine helps with memory, multitasking and mental performance under stress or fatigue.

These benefits appear to be more pronounced in challenging scenarios like sleep deprivation and overwork – matching well with many caffeine users’ needs.

Caffeine Plus L-Tyrosine restores caffeine-depleted neurotransmitters, regulates caffeine triggered stress hormones, and supports clarity during chaos, distraction and fatigue.

NutriGenesis® Caffeine Balance B-Complex

Caffeine’s diuretic effect may accelerate excretion of some vitamins and minerals. In one study, researchers linked coffee consumption with mild reductions in B-Vitamins Riboflavin, B6, Folate and B12:

Performance Lab® NutriGenesis® B-Vitamins

Concern: Caffeine may deplete essential B-Vitamins that support the healthy nervous system function, energy metabolism, and brain chemicals that drive a peak-performing stimulated state:

  • Folate – Supports serotonin, norepinephrine and dopamine
  • Vitamin B6 – Supports serotonin and norepinephrine; dopamine conversion
  • Riboflavin – Supports cell energy production and Vitamin B6 conversion
  • Vitamin B12 – Supports dopamine and serotonin

Caffeine Plus counterbalances caffeine depletion with Vitamins B9, B6, B2 and B12 as high-absorption NutriGenesis®.

Performance Lab® Caffeine Plus NutriGenesis® Caffeine Balance B-Complex is low-dose calibrated in order to:

  1. More precisely counter the mild caffeine-linked B-Vitamin depletions shown in research;
  2. Enable safer, better-tolerated Performance Lab® Caffeine Plus double-dosing and scalable stacking.

Performance Lab® NutriGenesis® B-Vitamins are complexed with cofactors that enhance absorption. NutriGenesis® bioavailability advantages are ideal for reversing caffeine-induced nutrient depletion.

Nutrigenesis Icon

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Performance Lab® Caffeine +

Ready to experience the future of caffeine? Take Stim solo or stack it seamlessly with other Performance Lab® formulas. Enjoy clean, balanced stimulation and perform better.

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Reviews

FAQ

Who should take Performance Lab® Caffeine Plus?

Caffeine Plus can help anyone seeking to enhance their overall performance and life vitality in a healthier way than traditional stimulants.

How do I take Performance Lab® Caffeine Plus?

Take 1 capsule for stimulation. Taken as directed, Caffeine Plus’s 50 mg caffeine serving size is effective for most. Those with greater tolerance or a higher optimal caffeine dose may take additional Caffeine Plus NutriCaps® in 50 mg caffeine increments up to 250 mg (5 NutriCaps®) per day, due to the formula’s scalable design.

Is Performance Lab® Caffeine Plus safe?

Like all Performance Lab® supplements, Caffeine Plus is designed to be safe for long-term daily use. Caffeine Plus achieves this with advanced formulation and stacking strategies that actually enhance caffeine, for safer, better-tolerated stimulant activity along with superior performance-enhancing stimulant benefits. Caffeine Plus’s clean design – free of GMOs, gluten, soy, colorants, preservatives and other additives – is also well-tolerated by the body; safe and beneficial for long-term use.

Is Performance Lab® Caffeine Plus legal?

Yes. Caffeine Plus is a safe, natural and 100% legal way to stimulate both body and mind.

Why only 50 mg of caffeine? I saw (another supplement) with 200 mg caffeine per serving.

More is not always better. High doses of caffeine can be counterproductive for human performance, triggering side effects that can make you shaky, irritable and unbalanced. Performance Lab® Caffeine Plus’s 50 mg of caffeine per serving is conservative by design, supplying equivalent caffeine between a cup of green tea and a cup of coffee. With this approach, Caffeine Plus helps you identify and manage your own optimal caffeine dose for superior performance benefits, whether you are taking it on its own or stacked with other caffeine sources.

What is NutriGenesis®?

NutriGenesis® is a Performance Lab® nutrition technology innovation: Vitamins, minerals and amino acids grown in live cultures at our state-of-the-art lab.

A true biological nutrient form, NutriGenesis® closely mirrors the molecular structure of food nutrients. NutriGenesis® nutrients offer significant advantages over standard nutrient forms.

Featured in several Performance Lab® formulas, NutriGenesis® vitamins, minerals and amino acids are bioengineered to be safe, active and highly effective for overall health and performance.

Why did Performance Lab® develop NutriGenesis®?

Vitamins, minerals and amino acids are the most important nutrients you need to build a strong foundation for health and performance.

Performance Lab® developed NutriGenesis® to have our own in-house vitamins, minerals and amino acids to use in our own nutritional supplements.

In producing NutriGenesis®, Performance Lab® can best maintain our industry-leading quality standards for cleanliness, purity, effectiveness and eco-friendliness, across all our ultramodern formulas.

How is NutriGenesis® different from other nutrient forms?

Not all vitamins, minerals and amino acids are the same. There are many nutrient forms, produced with a variety of processes. Some of the most popular nutrient forms available in supplements today include:

Whole Food Concentrates

Whole food vitamin and mineral supplements are sourced from fruits, vegetables, herbs and mushrooms. They include natural cofactors that make food nutrients so easy for the body to absorb and utilize. However, they do require extensive processing and may be made with GMOs, mass agriculture and dirty eco-destructive practices.

Isolated Chemical (USP) Nutrients

Isolated Chemical (USP) is the cheapest vitamin and mineral form found in the most basic multivitamin supplements. This synthetic form chemically alters vitamins and minerals, isolating them from their whole-food cofactors. As a result, Isolated Chemical (USP) nutrients are typically harder to absorb and less effective than whole food nutrients.

Chelated Minerals

In this process, a mineral nutrient (such as iron, calcium, zinc) is bound with a chelator: An organic molecule (often an amino acid) that is large enough to enrobe the mineral. By surrounding the mineral, the chelator protects it against degradation. Chelated nutrients are highly stable and may improve nutrient uptake and utilization.

NutriGenesis® is different from traditional nutrient forms: Bioengineered to be better.

NutriGenesis® are cultured nutrients that replicate the creation of vitamins, minerals and aminos in nature.

NutriGenesis® is based on the work of Nobel Prize-winning physiologist Albert Szent Gyorgy, who theorized that nutrients presented in their naturally grown forms supply cofactors that make them more bioavailable, biologically active and effective than nutrients that are isolated.

In the NutriGenesis® process, single-cell organisms are seeded with micronutrients in a hydroponic growth medium.

The live single-cell organisms “eat” the micronutrients, divide and thrive. As the cultures grow, they produce fresh new NutriGenesis® vitamins, minerals and aminos within a matrix of natural cofactors. This familiar structure is more easily absorbed and utilized by the body.

More on the NutriGenesis® Process

NutriGenesis® advantages over other forms:

NutriGenesis® is essentially food nutrition. Mirroring food nutrients molecule-by-molecule, our vitamins, minerals and aminos are presented in pure elemental form. Maximum nutrition: Nothing more, nothing less.

Enhanced effectiveness. Because NutriGenesis® nutrients are in food-matrix form, they are recognized by the body as nature-identical -- maximizing nutrient uptake, bioavailability and beneficial activity.

Patented and researched. The patented process behind NutriGenesis® has been shown in research to enhance nutrient absorption and retention (when compared to chemical isolates).

Cleaner and safer. NutriGenesis® is produced in a sterile, tightly controlled lab setting. NutriGenesis® is minimally processed, requiring no pesticides, herbicides or other synthetics associated with some other whole-food nutrients.

Better for the planet: The NutriGenesis® process is clean and efficient, with little carbon footprint or environmental impact – especially when compared to factory farming for phytonutrients and strip mining for minerals.

Which formulas feature NutriGenesis® nutrients?

It all begins with NutriGenesis® Multi for Men and Multi for Women: Performance Lab®’s multivitamin starting point for human performance optimization.

NutriGenesis® vitamins, minerals and amino acids are also found in Performance Lab® formulas Stim, Flex, BCAA, Pre, Post and Maintain.

Beyond Performance Lab®, NutriGenesis® B-Vitamins are found in Mind Lab Pro®: the Universal Nootropic™.

30-Day Performance Promise

Your first order of any Performance Lab® product is covered by our 30-day performance promise.

Put Performance Lab® Caffeine + to the test for a full 30 days and if you don’t see results, we’ll refund your money. No questions asked.

Simply get in touch with a member of our Customer Care team.

The Performance Lab® Performance Promise covers one container of any of our products, up to a maximum of three products per order. You’ll need to return any unused boxes.

Caffeine Plus stacks well with…

Caffeine Plus + Energy

Caffeine Plus is a stimulant-driven vitality formula with performance-enhanced caffeine. Energy is a stimulant-free vitality formula that works on a cellular level.

Combining Caffeine Plus + Energy gives you the best of both worlds.

Take Caffeine Plus + Energy together for a clean, balanced mind-body power surge that enhances performance across all athletic, cognitive and productive endeavors.

Learn More
Energy

Caffeine Plus + Mind

Mind is a caffeine-free nootropic for performance-driven cognition.

If you prefer caffeine with your nootropic, Caffeine Plus supplies it in ultramodern form for clean, balanced and productive stimulation.

Take Mind + Caffeine Plus to promote energized alertness that is clean, clear and calibrated for sharp cognitive function.

Learn More
Mind

Caffeine Plus + Vision

Caffeine Plus performance-enhanced caffeine promotes vigilance and energy.

Vision adds on novel support for visual reaction time, motion detection and dark adaptation.

Take Vision + Caffeine Plus together as an effective stack for all activities that benefit from calm alertness, sharp eyesight and quick reaction time.

Learn More
Vision

Research

The research and studies behind Performance Lab® Caffeine Plus.

Learn More

Caffeine

Goldstein ER et al. International society of sports nutrition position stand: caffeine and performance. Journal of the International Society of Sports Nutrition 2010 7:5.
Amendola CA et al. Caffeine’s Effects on Performance and Mood are Independent of Age and Gender. Nutr Neurosci. 1998;1(4):269-80.
Doherty M and Smith PM. Effects of caffeine ingestion on rating of perceived exertion during and after exercise: a meta-analysis. Scand J Med Sci Sports. 2005 Apr;15(2):69-78.
Smith A et al. Effects of a low dose of caffeine given in different drinks on mood and performance. Hum Psychopharm. 14(7);October 1999: 473–482.
Penetar D et al. Caffeine reversal of sleep deprivation effects on alertness and mood. Psychopharmacology (Berl). 1993;112(2-3):359-65.
Zwyghuizen-Doorenbos A et al. Effects of caffeine on alertness. Psychopharmacology (Berl). 1990;100(1):36-9.
Griffiths RR et al. Low-dose caffeine discrimination in humans. J Pharmacol Exp Ther. 1990 Mar;252(3):970-8
Marks V, Kelly JF (1973) Absorption of caffeine from tea, coffee, and coca cola. Lancet 1:827.
Fredholm BB, et al. Actions of Caffeine in the Brain with Special Reference to Factors that Contribute to its Widespread Use. Pharmacological Reviews March 1, 1999 vol. 51 no. 1 83-133.
Volkow ND, et al. Caffeine increases striatal dopamine D2/D3 receptor availability in the human brain. Translational Psychiatry (2015) 5, e549; doi:10.1038/tp.2015.46
Wisor JP, Nishino S, Sora I, Uhl GH, Mignot E, Edgar DM. Dopaminergic role in stimulant-induced wakefulness. J Neurosci 2001; 21: 1787–1794.
Ruxton, CHS. Cognitive function is not influenced by increasing caffeine dose. Nutrition Bulletin. 13 Feb 2008. 33: 15–25.
Haskell, CF, et al. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol Psychol. 2008 Feb;77(2):113-22. Epub 2007 Sep 26.
Mednick, SC, et al. Comparing the benefits of caffeine, naps and placebo on verbal, motor and perceptual memory. Behav Brain Res. 2008 Nov 3;193(1):79-86. doi:
10.1016/j.bbr.2008.04.028. Epub 2008 May 8.
Olson CA, et al. Effects of 2 adenosine antagonists, quercetin and caffeine, on vigilance and mood. J Clin Psychopharmacol. 2010 Oct;30(5):573-8.
Addicott MA, Yang LL, Peiffer AM, Burnett LR, Burdette JH, Chen MY, Hayasaka S, Kraft RA, Maldjian JA, Laurienti PJ. The effect of daily caffeine use on cerebral blood flow: how much caffeine can we tolerate? Hum Brain Mapp. 2009;30:3102–3114.
Mathew RJ, Wilson WH. Caffeine induced changes in cerebral circulation. Stroke. 1985 Sep-Oct;16(5):814-7.
Mayo Clinic Staff. Caffeine: How much is too much? Nutrition and healthy eating. Mayo Clinic. 1998-2015. 09 Sep 2015.

L-Theanine

Rao TP, Ozeki M, et al. In Search of a Safe Natural Sleep Aid. J Am Coll Nutr. 2015 Mar 11:1-12.
Nobre AC, et al.L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pacific Journal of Clinical Nutrition, 01/2008; 17 Suppl 1:167-8.
Kakuda T, Nozawa A, Sugimoto A, Nino H. Inhibition by theanine of binding of (3H)AMPA, (3H)Kainate and (3H)MDL 105,519 to glutamate receptors. Biosci Biotech Biochem, 2002;66:2683–2686
Kimura K. L-Theanine reduces psychological and physiological stress responses. Biol Psychol. 2007 Jan;74(1):39-45

L-Tyrosine

Harris R. Lieberman, et al. The catecholamine neurotransmitter precursor tyrosine increases anger during exposure to severe psychological stress. Psychopharmacology (Berl). 2015; 232(5): 943–951.
Mahoney CR, et al. Tyrosine supplementation mitigates working memory decrements during cold exposure. Physiol Behav. 2007 Nov 23;92(4):575-82. Epub 2007 May 22
Deijen JB1, Orlebeke JF. Effect of tyrosine on cognitive function and blood pressure under stress. Brain Res Bull. 1994;33(3):319-23
Thomas JR, et al. Tyrosine improves working memory in a multitasking environment. Pharmacol Biochem Behav. 1999 Nov;64(3):495-500.
Neri DF, et al.The effects of tyrosine on cognitive performance during extended wakefulness. Aviat Space Environ Med. 1995 Apr;66(4):313-9.
Lieberman H. Tyrosine and Stress: Human and Animal Studies. Institute of Medicine (US) Committee on Military Nutrition Research; Marriott BM, editor. Washington (DC): National Academies Press (US); 1994.
Reinstein DK, Lehnert H, Wurtman RJ. Dietary tyrosine suppresses the rise in plasma corticosterone following acute stress in rats. Life Sci. 1985 Dec 9;37(23):2157-63
Lorenza S. Colzato, et al. Working Memory Reloaded: Tyrosine Repletes Updating in the N-Back Task. Front Behav Neurosci. 2013; 7: 200

B-Complex

Ulvik A, et al. Coffee Consumption and Circulating B-Vitamins in Healthy Middle-Aged Men and Women. Clinical Chemistry Sep 2008, 54 (9) 1489-1496.
David O. Kennedy DO. B Vitamins and the Brain: Mechanisms, Dose and Efficacy—A Review. Nutrients. 2016 Feb; 8(2): 68.
Yarlagadda A, MD; Clayton AH, MD. Blood Brain Barrier - The Role of Pyridoxine. Psychiatry (Edgmont). 2007 Aug; 4(8): 58–60.
Leahy LG. Vitamin B Supplementation: What's the Right Choice for Your Patients? J Psychosoc Nurs Ment Health Serv. 2017 Jul 1;55(7):7-11.
Young S. Folate and depression—a neglected problem. J Psychiatry Neurosci. 2007 Mar; 32(2): 80–82.
Bottiglieri T. Folate, vitamin B₁₂, and S-adenosylmethionine. Psychiatr Clin North Am. 2013 Mar;36(1):1-13.
Valizadeh M, Valizadeh N. Obsessive Compulsive Disorder as Early Manifestation of B12 Deficiency. Indian J Psychol Med. 2011 Jul-Dec; 33(2): 203–204.
Deana R, et al. Levels of neurotransmitters in brain of vitamin B12 deficient rats. Int J Vitam Nutr Res. 1977;47(2):119-22.

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