Promote joint health and comfort from pain naturally across cartilage, ligaments, tendons, bones and more.

Joint supplements are more popular than ever this year.

People with active lifestyles want to strengthen joints, maintain flexibility and get relief from occasional joint pain, (and arthritis pain) osteoarthritis of the knee, aches and stiffness. 

But now, more people are looking to avoid synthetic over-the-counter joint relief supplement products due to their stomach-related side effects, ulcer risks and serious adverse events.1

Even in natural products, many are switching from animal byproduct joint supplements (from shellfish, bovine tissues, etc.) to vegan- and eco-friendly plant-based joint supplement alternatives. 

As a result, today's best joint supplements are cleaner and more effective than ever, helping to support, soothe, regenerate and lubricate joints for both daily performance and continued long-range health. 

    Joint supplements this year feature new ingredient forms that are more powerful, formulated in novel combos to work in new ways.

    The best joint supplement ingredients include the following products:

    • Boswellia Serrata - Traditional herb with active AKBA that soothes joints and blocks joint-destructive 5-LOX enzymes2
    • Curcumin - Turmeric root antioxidant (and anti inflammatory) soothes and protects joints from COX-2 enzymes and free radicals3
    • Glucosamine - Foundational building block for cartilage cells, connective tissues and joint-lubricating synovial fluid4
    • Chondroitin - Connective tissue building block attracts water like a magnet; chondroitin helps keep cartilage hydrated and cushy5
    • MSM - Organic sulfur molecule that is used in the formation of all connective tissues6
    • Strontium - Essential mineral for bone health; helps strengthen subchondral bone under joint cartilage7
    • Multivitamin - Vitamins and minerals support joint-building collagen, bone health and overall skeletal strength8

    Let's take a closer look at each of these individual joint supplements and the new forms that make them more effective for your health than ever. 

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    Our Guide to the Best Individual Joint Supplement Products

    Curcumin pictured in its many different forms such as the root and powder as a joint support supplement

    Boswellia Serrata

    Also known as frankincense, this traditional Ayurvedic herb produces a resin that contains a powerful active ingredient called AKBA (3-O-acetyl-11 keto-ß-boswellic acid).9

    AKBA is noted for fighting 5-LOX and MMP: Joint-damaging enzymes associated with degeneration and discomfort.10

    Boswellia serrata is a research-backed botanical joint supplement, shown in human clinical trials to:11

  • Soothe away joint aches
  • Enhance joint performance as flexion
  • Improve mobility and performance of daily activities
  • Best Boswellia for Joints: AprèsFlex®

    AprèsFlex® is a unique Boswellia serrata extract bioengineered to achieve 52% greater absorption than plain frankincense resin.

    AprèsFlex® is also standardized to 20% AKBA: A precise amount of active ingredient for reliable and consistent joint support in every serving. 

    Curcumin (from Turmeric)

    Curcumin is a complex of antioxidants found in turmeric: The bright yellow root spice and anti inflammatory used in Indian cuisine and Ayurvedic herbal health traditions for centuries.

    Modern research has shown that curcuminoids derived from turmeric (which include curcumin) hold great potential for helping with flexibility, joint pain (eg. knee pain) and joint health. It's used in supplements for arthritis as a result. 

    Like Boswellia, curcumin helps modulate joint inflammation while fighting joint-destructive free radicals and cartilage-eating enzymes.

    But where Boswellia targets 5-LOX enzyme, Curcumin fights two separate, but equally joint-destructive, enzyme classes:12

    1. COX-2 enzymes
    2. Matrix metalloproteinase (MMP) enzymes

    Curcumin joint protection appears to help with comfortable flexibility and relieve pain: Studies have found researchers to suggest curcumin from turmeric root may have similar joint relief effects as analgesics.13

    In addition, large reviews of clinical research studies suggest that curcumin and its anti inflammatory benefits help with many aspects of long-range joint health, including in people with degenerative joint concerns such as joint pain and inflammation, arthritis and osteoarthritis.14

    Best curcumin for joint health: CurcuWIN®

    Curcumin's potency has always been somewhat limited because it is notoriously hard for the body to absorb.

    CurcuWIN® is a branded supplement form of curcumin that offers a significant upgrade over plain turmeric powder:

    • CurcuWIN® is produced with nutrition technology that improves curcumin absorption by 42%

    CurcuWIN® is also a precise extract, delivering 20% total curcuminoids in ratios that match what is found in nature.

    AprèsFlex® Boswellia Serrata + CurcuWIN® Curcumin: A Joint Comfort Innovation

    Modern over-the-counter synthetic remedies for joint aches and pain are increasingly shown to be risky for your stomach lining.15

    AprèsFlex® Boswellia Serrata + CurcuWIN® Curcumin present an herbal supplement alternative for joint pain relief.

    AprèsFlex® and CurcuWIN® soothe away joint pain aches and stiffness. But unlike some stomach-irritating synthetic joint remedies, AprèsFlex® and CurcuWIN® are safenatural and organic: Easy to absorb, Easy on the stomach and healthier for long-range use.

    Glucosamine Sulfate

    Glucosamine Sulfate is a prized joint health ingredient for supporting joint structure, optimizing joint comfort, and nourishing joint cartilage.

    It works by stimulating cartilage cells to produce protein building blocks that are used to form fresh cartilage and connective tissues in the body.

    Ultimately, glucosamine may help to reinforce the very structure of joints to help support them and them work better.

    Researchers have suggested glucosamine may help with flexibility in several different ways, including:16

    • Optimizing chondrocyte cells that produce cartilage
    • Serving as a building block for connective tissues
    • Optimizing repair, regeneration and lubrication of cartilage
    • Blocking some cartilage-destroying enzymes
    • Supplying some joint-protective antioxidant activity

    Best Glucosamine for Joint Supplements: Anything Vegan-Friendly

    Most glucosamine supplements are sourced from shellfish. But not everybody is comfortable taking health supplements sourced from bottom-feeding crustaceans.

    You'll find that there are several vegan-friendly glucosamine alternatives available in supplements. Look for any form labeled as vegan-friendly for the cleanest possible glucosamine experience.


    Another important connective tissue building block, chondroitin supplements help to build proteoglycans: Protein molecules that make cartilage plump, cushiony and comfortable.

    Like glucosamine, chondroitin blocks cartilage-destroying enzymes. Chondroitin appears to have inflammation-modulating activity that may further help to soothe away joint aches (eg. knee osteoarthritis) and pain in the body.17

    Best chondroitin in joint supplements: Mythocondro®

    Mythocondro® boosts chondroitin bioavailability by 43%, enabling superior joint support at a lower dosage.

    Mythocondro® is also the only vegetarian chondroitin.

    Other chondroitin forms have animal origins including pork byproducts, shark cartilage and bovine connective tissue.

    Joint Support Stack Synergy: Glucosamine + Chondroitin work better together.

    The 2006 GAIT study conducted by the US National Institutes of Health found that glucosamine and chondroitin are more effective for joint comfort when taken together.

    In this study, both glucosamine and chondroitin worked solo, but the combination of both worked even better. Researchers reported the moderate-to-severe joint aches group, 79% of subjects had a 20% or greater reduction in joint discomfort (compared to 54% for placebo).18


    Methylsulfonylmethane (MSM) is an organic compound, comprised of about 34% bioavailable organic sulfur.

    Organic sulfur is essential to all living things on Earth – including us humans. MSM is the third most abundant mineral in our bodies.

    Supplementing with MSM helps to restore organic sulfur to optimal levels in joints and connective tissues in the body. Research suggests MSM supplements may:19

    • Support healthy joints and range of motion
    • Counter the effects of cartilage breakdown
    • Counter effects of destructive free radicals with some joint-protective antioxidant activity

    MSM is also included in the best joint supplements to help maintain the healthy resilience of all other connective tissues in the body, including skin, cartilage, ligaments and tendons.

    Best MSM for Joint Supplements: OptiMSM®

    Premium-quality OptiMSM® is the purest (99.7% pure) and only GRAS-designated MSM supplement, made in the USA with a proprietary multi-stage distillation process that yields superior purity, quality and consistency.

    In a randomized, double-blind, placebo-controlled pilot trial on MSM effectiveness for joint comfort, 50 subjects took OptiMSM® for 12 weeks, increasing dosage to a peak of 6 g daily. Subjects taking OptiMSM® reported improved joint comfort versus placebo. Researchers concluded MSM may warrant further study as a joint enhancer.20


    Strontium is a bone health mineral. It helps with the skeletal aspects of joint health and performance - and people with osteoarthritis of the knee. 

    Strontium is suggested to work by helping both the osteoblast cells that build bone and the osteoclast cells that break down cells in the body.21

    Animal studies have suggested that strontium may help to both preserve cartilage tissues and support the subchondral bone (bone underneath cartilage) that contributes to its healthy function.22

    Multivitamin Nutrients

    In addition to strontium, several other essential vitamins and minerals can help to support joint health, skeletal strength and overall comfortable flexibility. They are:
    • Calcium - Crucial essential mineral for bones, which help comprise strong joints
    • Vitamin D3 - Assists with absorption of calcium, crucial for bone support
    • Magnesium - Crucial skeletal mineral functions as a bone builder and strengthener
    • Vitamin K - Helps keep calcium in bones and out of bloodstream
    • Vitamin C - Supports collagen production, in turn optimizes joint structure and shock-absorbing capability

    Best Strontium and Multivitamin Nutrients for Joint Health: NutriGenesis®

    NutriGenesis® is ultramodern nutrition technology unique to Performance Lab®. NutriGenesis® vitamins and minerals are fermented on cultures in a clean lab setting, and bioengineered with cofactors that boost absorption and maximize benefits. 

    Best Overall Joint Support Supplement:
    Performance Lab® Flex

    Performance Lab® Flex is a long term flexibility formula that combines all of the best individual joint health supplements into one powerful stack:
    • ApresFlex® Boswellia Serrata, 100 mg
    • CurcuWIN® Curcumin, 250 mg
    • Mythocondro® Chondroitin Sulfate, 100 mg
    • OptiMSM® Methylsulfonylmethane (MSM), 100 mg
    • NutriGenesis® Strontium, 300 mcg

    Get the Best Performance Lab Flex Deal Now

    Flex soothes joints to reduce joint pain and stiffness and protects achy joints with easy-on-the-stomach botanicals, and lubricates and nourishes joints with the most important joint building blocks.

    All for optimal joint function.

    Performance Lab® Flex ultramodern joint nutrients are curated and combined for active joint demands, helping to:

    • Promote faster-acting, longer-lasting joint and pain relief with powerful botanical extracts*
    • Fight 3X joint-destructive enzyme classes: 5-LOX, COX-2, MMP 
    • Support flexible and resilient ligaments, tendons and connective tissues*
    • Optimize joint-lubricating synovial fluid for smooth, comfortable motion*
    • Maintain cushy, hydrated cartilage to help with joint shock absorption*

    Flex is also the cleanest joint supplement in the universe. 

    You can take this supplement every day (2 capsules per day) in good health, and reap the greater flexibility benefits that build with continued use over time:

    • Nourishes cartilage, connectives tissues and bone to help maintain overall joint health*
    • Natural joint relief that is easy on the stomach, unlike some harsh synthetics*
    • Clean vegan-friendly formula. Some other joint supplements have dubious animal origins
    • 100% natural prebiotic-infused NutriCaps® made from pullulan (fermented tapioca) 

    Get the Best Performance Lab Flex Deal Now

    Best Multivitamin for Joints: 
    NutriGenesis® Multi

    NutriGenesis® Multi augments Flex with 17+ essentials, including the most important vitamins and minerals for:

    • Bone strength
    • Collagen production
    • Connective tissue resilience
    • Overall joint health

    Taking a clean, highly absorbable multivitamin like NutriGenesis® Multi per day forms a strong nutritional support foundation for continued, long-range joint health and flexibility.

    Get the Best Performance Lab Multi Deal Now

    Conclusion of our Products Review

    The best joint supplements this year can help you in the short-term with both flexibility and comfort, as well as helping long-range joint health to keep you in motion for the long haul. 

    Take Flex + NutriGenesis® Multi for far-reaching flexibility support ranging from joint basics to the most advanced forms of today’s greatest joint-soothing botanicals and joint-building raw materials.