Contents

Vitamins for Tired Legs

  • 12 minute read
  • image of Performance Lab
    Written by Performance Lab
Vitamins for Tired Legs

There is nothing worse than working out and feeling like you could go for another hour, but your legs are tired and can't keep up.

While this may be normal after a hard leg workout, feeling as though your leg's fatigue much quicker than usual indicates a slightly bigger issue, and there are a few things that can be contributing to this.

Read on to find out all you need to know about tired legs and the best vitamins to help!

Best Vitamins for Tired Legs: Key Takeaways

  • Vitamin D, B1, B3, B12, and E support energy metabolism, circulation, and recovery. [1, 2, 3]
  • A good multivitamin fills minor gaps if food alone isn’t enough. [4]
  • Tired legs can often be traced back to hydration, electrolytes, or iron. [5, 6]
  • Losing electrolytes through sweat means your muscles run out of fuel quicker. [7]
  • Drinking too little or too much water both throw things off balance. [8, 9]
  • Low iron is another big cause of feeling weak and drained. [5]
  • Make sure to get 7-9 hours of quality sleep per night to help your legs recover. [10]
  • Muscle overuse and underuse can both contribute to tired legs. [11, 12]
  • Pairing dietary supplements with hydration and electrolytes helps you push through leg day without the crash.
  • Start with the key vitamins that support circulation and energy, then build the rest of your plan around sleep, hydration, and food.
Nourish Tired Legs, Supported By Performance Lab® NutriGenesis® Multi

Essential vitamins. Core minerals. Supplied with NutriGenesis® Multi to help cover nutrient needs involved in normal energy output.

Includes key nutrients like vitamin D, B-complex, and iron.
Made with NutriGenesis® technology for bioavailable and easy-to-digest nutrients.
100% plant-based, clean-label capsules for daily use. 
Performance Lab NutriGenesis Multi supplement bottle

Tired Legs: Possible Causes

Man sitting outside holding his leg, showing muscle fatigue and tired legs.

Hydration, Electrolytes, and Energy Levels

The first thing to investigate is your hydration and electrolyte status. When we work out, we lose water and electrolytes, like sodium, much quicker through our sweat and as our body uses them. Electrolytes are an important part of our body and include sodium, potassium, magnesium, phosphate, and calcium.

These minerals play a vital role in fluid balance, proper muscle contraction, muscle movement, and nerve transmission, and some of them (like essential mineral magnesium) support cellular energy production when you’re training or on your feet all day. [13, 14]

Electrolytes have an electrical charge when they are in water which helps our bodies regulate chemical reactions and maintain fluid balance in cells. These levels can change how our muscles react to working out, and low levels can lead to tiredness and muscle cramps much quicker than usual.

Dehydration and Overhydration

Hydration also plays a role in this. When you are dehydrated, it correlates to high electrolyte levels, and overhydration can result in low levels.

Consuming a sports drink that has electrolytes added into it will help to hydrate you and provide your body with the necessary electrolytes to keep your muscles functioning optimally. Many athletes do well with a gentle magnesium form (like glycinate or citrate).

Other sports products like gels and powders will also provide electrolytes, and when taken with water, will provide hydration as well!

Get regular insight, offers & access to sales. Plus 10% off your first order.
image of Performance Lab® capsules

Iron Levels

The last thing to consider is iron status. Low iron, or iron deficiency anemia, can cause us to feel tired and weak, making working out much more difficult.

Other common symptoms include headaches, pale skin, cold hands, shortness of breath, and heart palpitations.

You might be at increased risk if you’re female, have heavy periods, donate blood, are vegan or vegetarian, or train hard without eating iron rich foods. [5, 16, 17]

Start with nutrition; choosing foods rich in iron (lean red meat, egg yolks, beans, leafy greens) and pair with vitamin C to absorb more. Citrus or peppers are easy dietary sources.

Sleep and Recovery for Tired Legs

Athlete lying on the court after a match, exhausted and experiencing leg fatigue.

Many people think that by doing more activity they will beat tired legs. And while this may be true in the case of underuse (explained soon), it can be counterproductive if you're already very physically active.

It's during deep sleep that your legs and other muscles repair most effectively. In addition, sleep is one thing that helps to protect and restore your mitochondria, small power plants in your cells that produce energy in the form of ATP molecules. [15]

Without enough rest (especially sleep), your legs can't fully recover from training or daily exertion. A physical job or long hours on your feet can be just as strenuous as a workout.

Quality sleep is one thing that is commonly neglected in today's world. Unfortunately, this builds up fatigue and makes your legs feel heavy faster, and may even worsen issues like restless leg syndrome.

To support circulation, hormone balance, and leg recovery, aim for 7-9 hours of consistent, good-quality sleep.

  • Pairing adequate rest with proper nutrition and hydration gives your legs the best chance to perform at their peak.

Underuse Tires Your Legs, Too

Before we move on to vitamins for tired legs, there's another lifestyle factor that could be making your legs feel tired: underuse. It might seem logical that the more we rest, the more energy we'll have, but this is only up to a point.

The less you exert your muscles, the fewer the mitochondria, and the less efficient these mitochondria become.

The good news is, it also works the other way around; putting your legs to work increases the demand for energy, therefore your body will create more mitochondria and increase the efficiency of existing ones to meet that requirement. [18]

If you spend most of the day sitting, make an effort to stand up or move for 5 minutes every hour, if possible. Exercise at least 15 minutes every day, or do more vigorous exercises for 45-60 minutes, 2-3 times per week to boost endurance capacity.

Essential Vitamins That Can Help Tired Legs & Muscle Function

Different vitamin capsules on a plate, supporting energy and tired leg recovery.

Besides electrolytes and hydration, some essential vitamins could also help with tired legs. A blood test can also be done to check for vitamins deficiency or broader nutrient deficiencies. If you're dealing with any, certain vitamins and key nutrients can make a difference:

Vitamin D (Sunshine Vitamin)

Wooden blocks spelling Vitamin D, a key nutrient for muscle health and tired legs.

Vitamin D is an essential nutrient for overall health that regulates calcium absorption, indirectly helping electrolyte balance. It can be taken in a supplement form, as D3, and by making sure you consume enough milk, yogurt, cheese, eggs, and fatty fish in your diet. Consider getting your blood vitamin D levels checked to determine whether you may need extra support.

Vitamin B1

Natural sources of Vitamin B1 including eggs, nuts, lentils, and orange slices for energy support.

Also known as thiamine, vitamin B1 deficiency can indirectly contribute to weak legs and arms in a condition called dry beriberi. [19] Vitamin B1 works in concert with B6 and B12 to support a healthy nervous system.

Adequate intake of thiamine helps support normal energy metabolism and may help with leg fatigue. B1 can be found in lentils, brown rice, white rice, wheat, and peas.

Vitamin B3

Foods rich in Vitamin B3 like grains, nuts, and dried fruit to improve circulation and reduce leg fatigue.

This B-vitamin is also called niacin and plays a role in supporting blood circulation throughout your body; one way it does this is by dilating blood vessels. [20]

A deficiency in niacin can potentially contribute to low energy and stiffness. Sources of B3 include beef, liver, chicken, egg, and dairy. However, too much niacin is also linked to negative side effects so it's important to not overdo it with supplements.

Vitamin B12

Animal-based foods high in Vitamin B12, essential for nerve function and tired leg relief.

B12 helps make red blood cells that carry oxygen to working muscles and supports healthy nerve function. When it’s low you may notice muscle weakness, unsteady legs, pins and needles, or other unpleasant sensations. [12]

Consider vitamin supplements if you’re in one of the higher risk groups, including plant-based, older, on metformin or acid-reducing meds, or those having gut issues. Foods include eggs, dairy, fish (rich in omega-3 fatty acids), and fortified plant milks/cereals.

Vitamin E

Nuts, seeds, and dried fruits rich in Vitamin E, helping reduce oxidative stress.

Vitamin E supports healthy cardiovascular system, and may indirectly aid normal blood flow by reducing cholesterol oxidation and plaque formation. [22] It's important to mention, though, that results in studies are mixed, and high-dose supplementation has not consistently been shown to reduce muscle soreness or speed recovery. That's why it's last on the list.

We've included vitamin E here as it's a common addition to vitamin supplements, but it's important to recognize its limitations and that other nutrients are more directly relevant for leg fatigue. Sources of vitamin E include peanuts, almonds, spinach, and sunflower seeds.

Additional Things to Consider

Runner stretching his calf muscles to ease leg tension and support recovery.

Balanced Diet for Energy Production (Carbs + Protein)

Glycogen is a crucial source of energy in your muscles. [23] Your body typically gets glycogen from eating carbohydrate-rich foods.

If you're not consuming enough carbs to meet demands of physical activity, your legs can fade early even if lungs feel fine.

Load up on quality carbs — whole-grain pasta, sweet potatoes, fruits, etc. — before training or long shift at work. Afterwards, restock with additional carbs and proteins to help with recovery, protein synthesis, and keep legs happier tomorrow. The proteins and healthy fats help your body process carbs more steadily without spikes and crashes in blood sugar.

If your appetite is low post-shift or post-workout, consider going liquid: smoothie with a banana, blueberries, greek yogurt, barley, avocado or nuts, and chia seeds.

Job Demands Count as Physical Activity

Long shifts, stairs, and heavy carries are still leg work; therefore, plan your week accordingly. If you like to exercise, reduce gym volume on heavy-shift days or move leg day to when you're fresh.

One simple tip: Keep healthy snacks + electrolytes at work, as mini fueling beats running empty.

Fatigue Persisting? Here's What You Should Know

If your hydration status is topped up, diet is on point, sleep is consistent, and all of the above factors are checked, and leg fatigue still lingers, it's time to call your doctor. Ask them about ferretin, hemoglobin, transferring saturation (iron status), plus vitamin D.

Consider checking your B12 levels (especially if vegan) and thyroid function to rule out any deeper issues behind your muscular weakness.

Your doctor may suggest solutions like adjusting nutrition, compression massage, or even wearing compression stockings if circulation is an issue.

The Take-Home

Person running outdoors at sunrise, symbolizing energy, strength, and relief from tired legs.

While you can get all of the above vitamins from foods, if you are experiencing muscle fatigue in your legs, you may be lacking in one or more and can take advantage of supplements for an extra boost!

A multivitamin will contain all these vitamins, some of which may be helpful in reducing leg fatigue. Our top pick is Performance Lab NutriGenesis Multi.

This multivitamin contains all the above vitamins and more to help fill in the gaps your diet is missing, providing you with 100% of the daily recommended value for 17 essential vitamins and minerals.

Taking a supplement alongside improving your hydration and electrolyte intake will support your legs in getting through your next leg day without any fatigue!

Performance Lab® NutriGenesis Multi

The world's most advanced multivitamin formula.

Shop Now
80 reviews
Image of Performance Lab® NutriGenesis Multi

References

  1. Sheeley, M. P., Andolino, C., Kiesel, V. A., & Teegarden, D. (2022). Vitamin D regulation of energy metabolism in cancer. British journal of pharmacology, 179(12), 2890–2905. https://doi.org/10.1111/bph.15424
  2. Tardy, A. L., Pouteau, E., Marquez, D., Yilmaz, C., & Scholey, A. (2020). Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence. Nutrients, 12(1), 228. https://doi.org/10.3390/nu12010228
  3. Office of Dietary Supplements. (2021, March 26). Vitamin E—Health professional fact sheet. National Institutes of Health. U.S. Department of Health and Human Services. Retrieved [today’s date], from https://ods.od.nih.gov/factsheets/VitaminE-HealthProfessional/
  4. Ward E. (2014). Addressing nutritional gaps with multivitamin and mineral supplements. Nutrition journal, 13, 72. https://pubmed.ncbi.nlm.nih.gov/25027766/
  5. Świątczak, M., Młodziński, K., Sikorska, K., Raczak, A., Lipiński, P., & Daniłowicz-Szymanowicz, L. (2022). Chronic Fatigue Syndrome in Patients with Deteriorated Iron Metabolism. Diagnostics (Basel, Switzerland), 12(9), 2057. https://doi.org/10.3390/diagnostics12092057
  6. Jung, A. P., Bishop, P. A., Al-Nawwas, A., & Dale, R. B. (2005). Influence of Hydration and Electrolyte Supplementation on Incidence and Time to Onset of Exercise-Associated Muscle Cramps. Journal of athletic training, 40(2), 71–75. https://pmc.ncbi.nlm.nih.gov/articles/PMC1150229/#:~:text=Because%20EAMCs%20are%20a%20temporarily,of%20activity%20usually%20precipitate%20EAMCs
  7. Choi, D.-H., Cho, J.-Y., Koo, J.-H., & Kim, T.-K. (2021). Effects of electrolyte supplements on body water homeostasis and exercise performance during exhaustive exercise. Applied Sciences, 11(19), 9093. https://doi.org/10.3390/app11199093
  8. Rosner M. H. (2019). EXERCISE-ASSOCIATED HYPONATREMIA. Transactions of the American Clinical and Climatological Association, 130, 76–87.
  9. Maughan, R. J., & Shirreffs, S. M. (2010). Dehydration and rehydration in competative sport. Scandinavian journal of medicine & science in sports, 20 Suppl 3, 40–47. https://doi.org/10.1111/j.1600-0838.2010.01207.x
  10. Doherty, R., Madigan, S. M., Nevill, A., Warrington, G., & Ellis, J. G. (2021). The Sleep and Recovery Practices of Athletes. Nutrients, 13(4), 1330. https://doi.org/10.3390/nu13041330
  11. Bogdanis G. C. (2012). Effects of physical activity and inactivity on muscle fatigue. Frontiers in physiology, 3, 142. https://pmc.ncbi.nlm.nih.gov/articles/PMC3355468/
  12. Orejel Bustos, A., Belluscio, V., Camomilla, V., Lucangeli, L., Rizzo, F., Sciarra, T., Martelli, F., & Giacomozzi, C. (2021). Overuse-Related Injuries of the Musculoskeletal System: Systematic Review and Quantitative Synthesis of Injuries, Locations, Risk Factors and Assessment Techniques. Sensors (Basel, Switzerland), 21(7), 2438. https://doi.org/10.3390/s21072438
  13. Open Resources for Nursing (Open RN), Ernstmeyer, K., & Christman, E. (Eds.). (2021). Nursing Fundamentals(Chapter 15: Fluids and Electrolytes). Chippewa Valley Technical College. Retrieved September 2, 2025, from https://www.ncbi.nlm.nih.gov/books/NBK591820/
  14. Fatima, G., Dzupina, A., B Alhmadi, H., Magomedova, A., Siddiqui, Z., Mehdi, A., & Hadi, N. (2024). Magnesium Matters: A Comprehensive Review of Its Vital Role in Health and Diseases. Cureus, 16(10), e71392. https://doi.org/10.7759/cureus.71392
  15. Richardson, R. B., & Mailloux, R. J. (2023). Mitochondria Need Their Sleep: Redox, Bioenergetics, and Temperature Regulation of Circadian Rhythms and the Role of Cysteine-Mediated Redox Signaling, Uncoupling Proteins, and Substrate Cycles. Antioxidants (Basel, Switzerland), 12(3), 674. https://doi.org/10.3390/antiox12030674
  16. National Heart, Lung, and Blood Institute. (n.d.). Iron-deficiency anemia. National Institutes of Health. Retrieved September 2, 2025, from https://www.nhlbi.nih.gov/health/anemia/iron-deficiency-anemia
  17. Wiafe, M. A., Ayenu, J., & Eli-Cophie, D. (2023). A Review of the Risk Factors for Iron Deficiency Anaemia among Adolescents in Developing Countries. Anemia, 2023, 6406286. https://doi.org/10.1155/2023/6406286
  18. Porter, C., Reidy, P. T., Bhattarai, N., Sidossis, L. S., & Rasmussen, B. B. (2015). Resistance Exercise Training Alters Mitochondrial Function in Human Skeletal Muscle. Medicine and science in sports and exercise, 47(9), 1922–1931. https://doi.org/10.1249/MSS.0000000000000605
  19. Wiley, K. D., & Gupta, M. (2023, July 17). Vitamin B1 (Thiamine) Deficiency. In StatPearls [Internet]. StatPearls Publishing. Retrieved September 2, 2025, from https://www.ncbi.nlm.nih.gov/books/NBK537204/
  20. Peechakara, B. V., & Gupta, M. (2024, February 29). Vitamin B3. In StatPearls [Internet]. StatPearls Publishing. Retrieved September 2, 2025, from https://www.ncbi.nlm.nih.gov/books/NBK526107
  21. Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline. (1998). Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline (Chapter 9: Vitamin B12). National Academies Press. Retrieved September 2, 2025, from https://www.ncbi.nlm.nih.gov/books/NBK114302/
  22. Kumar, M., Deshmukh, P., Kumar, M., Bhatt, A., Sinha, A. H., & Chawla, P. (2023). Vitamin E Supplementation and Cardiovascular Health: A Comprehensive Review. Cureus, 15(11), e48142. https://doi.org/10.7759/cureus.48142
  23. Mul, J. D., Stanford, K. I., Hirshman, M. F., & Goodyear, L. J. (2015). Exercise and Regulation of Carbohydrate Metabolism. Progress in molecular biology and translational science, 135, 17–37. https://doi.org/10.1016/bs.pmbts.2015.07.020

No comments yet. Be the first to comment!

Leave a Comment